#
Mathematical problems arising from biochemical reaction networks

March 25 to March 29, 2013
at the

American Institute of Mathematics,
Palo Alto, California

organized by

Alicia Dickenstein,
Jeremy Gunawardena,
and Anne Shiu

## Original Announcement

This workshop will be devoted to the mathematical analysis of biochemical reaction networks arising in systems biology. Specifically, we are interested in classes of nonlinear dynamical systems that arise from biologically-relevant networks of chemical reactions, parametrized by rate constants that are usually unknown and difficult to measure. The nonlinearities in these systems have hindered mathematical analysis of network behavior, which has largely been studied by numerical simulation.
Recent developments have suggested that mathematical analysis of such networks may be feasible, using methods from computational algebra, algebraic geometry and dynamical systems. For instance, one class of dynamical systems, coming from mass-action kinetics, gives rise to polynomial dynamical systems. Here, the biologically-relevant steady states are the positive real solutions to a system of polynomial equations and from computational algebra and algebraic geometry have been used to shed light on steady-state behaviour. Difficult questions still remain regarding the transient dynamics and generalisations to non mass-action systems.

The primary aim of this workshop is to bring together mathematicians as well as researchers who are closer to the experimental side of systems biology, in order to formulate precise open problems and to explore appropriate mathematical methods to tackle them. We hope to sustain an open dialogue between theory and experiment, so that they may continue to stimulate each other. Among the problems we may consider initially are the following.

- Decomposition of parameter spaces according to qualitative dynamical behaviour.
- Computation of steady state polynomial invariants.
- The Global Attractor Conjecture.
- Elimination theory and the QSSA (quasi-steady state approximation) approach.
- Extension of mass-action kinetics results to more general kinetics.

## Material from the workshop

A list of participants.
The workshop schedule.

A report on the workshop activities.

Papers arising from the workshop: