January 5 to January 9, 2015
American Institute of Mathematics,
San Jose, California
and Chae-Ok Yun
This workshop will be devoted to mathematical and computational modeling of tumor-immune
dynamics. Recent research in cancer immunology and immunotherapy strongly
suggests that the immune system plays a fundamental role in combating tumors,
and hence could be used as a vehicle to prevent or cure cancer. However,
fundamental questions concerning complex interactions between the immune system
and tumors remain. For example, several current research directions seek to
investigate how components of the immune system synergize to limit cancer
development, how tumors escape immune recognition and control, and why some
immunotherapies can inhibit the progression of certain tumors while stimulating
the growth of others. The multidimensional, nonlinear nature of these
interactions will require cross-disciplinary collaboration and approaches to
understand key interactions, and capture more realistic dynamics of the
The main topics for the workshop are:
- Exploring the use of partial differential equations and/or agent-based
models in conjunction with or as alternatives to ordinary differential equations
when developing tumor-immune models,
- Identifying key questions in cancer immunology and immunotherapy that are
suitable and timely for mathematical modeling,
- Assessing modeling approaches and methods that are appropriate to address
these biological and medical questions,
- Determining what types of experimental studies and can inform model
Mathematical models that are informed by the current state-of-the-art in cancer
immune research will be intentionally directed toward important questions and
will provide a platform for ongoing and increasing dialogue between
mathematicians, biological scientists, and clinicians.
Material from the workshop
A list of participants.
The workshop schedule.
A report on the workshop activities.